I had the antibody test and tested negative for both HSV 1 and 2. The infectious disease specialist said it was probably too early and I should test three months later. That test came back negative again for HSV 1 and 2. The doctor said I definitely had neither form of herpes simplex, and the positive test was most likely because of the shingles. This is unusual because I was nearly 50 years old, and by that age almost 80% of the population will have had HSV 1.
So wait....if they're the exact same virus why did my doctor run two tests at my last physical? HSV-1 positive, HSV-2 negative ?????
HSV-1 and HSV-2 are exactly the same virus- just different strains. I usually explain it in the same way that we explain head lice vs pubic lice- same organism, just adapted to affect different parts of the body.
In testing for viruses, we have two choices- to test for the virus itself (expensive) or test for antibodies to the virus (cheaper). Most first round tests are antibody tests- we're looking to see if you have had an exposure that triggered your immune system to respond and create antibodies.
If a person has a lesion that we're unsure of whether it's herpes zoster (shingles, chickenpox) or herpes simplex (cold sores, herpes gladitorium, anogenital herpes, etc) then we would take a sample of the lesion and send it for
antigen testing. An antigen test can either be a culture or a PCR-type test that looks for viral DNA.
if the person doesn't have an active lesion and we're looking to see has had an exposure to HSV in the past, we would do an antibody test. There are different types of antibodies. One of the tests is able to distinguish between a particular type of antibody for HSV-1 vs HSV-2.
So why do people freak out about herpes if 80% of the population has it and it's as common as a cold? I don't get it.
Back to the lice comparison. If you get head lice, people likely won't judge you. If you get pubic lice, you're treated differently.
If you get HSV on your lip, people will go "ewww" but chances are that you won't be treated differently. If you get HSV on your dick, people have a different attitude about it. It's part of the hangup that we have about sex and sexually transmitted diseases.
From a medical perspective, the only reason we really care about anogenital herpes is that in women, it can pass to a newborn during a vaginal delivery. HSV can cause lethal complications in a newborn (e.g. meningitis).
Other than the pregnancy concern, there's little difference to us. It's the same virus and the treatment is the same.