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Having been off and on depressed for about 7 years, yes, depression is a selfish illness. The reason why I say depression is a 'selfish illness' is simply put "It is like living life inside your own bubble." Cliché yes but definately true.
Obviously there are a multitude of factors that can contribute to depression, so answering this question easily is not gonna happen. Not to mention there are different types of depression. If this has been going on for a long period of time (greater than a year), this is not an 'isolated event' but rather an 'on-going problem'.
I think the first thing to check out is if there are any genetic disorders that are in your family that may contribute to your brother's depression. After that, consulting a family doctor may be a good place to start.
I will offer this advice. Don't ask a depressed person to talk about their problems, no matter how concerned you are. Most will blatantly lie about their feelings and force them deeper into denial (making the bubble harder to pop). If they want to open about it with you, they will when they want to. The best metaphor I got is like someone who is in the closet.
My advice, just spend time with the person doing things they enjoy. It will make both of you happy.
Most people have an 'x-factor' that contributes to their depression. I know what can 'trigger' my depression and I know how to cope with it also. Unfortunately if the 'trigger' is a person (which could be a high posibility in your case) it is best to have those people not see each other at all.
