I am usually on the go for some 200 days a year on business. Mostly in Europe and in the US. In addition to that my BF and I would travel the world for some 50-60 days a year for pleasure. I have been living on this travel schedule for 15 years now. For the last five years my BF has been going along, too. 
So, I 'live' in a more traditional sense for only 100+ days a year. I used to spend some 90+ days a year at my home in San Francisco, CA. The remaining few days, plus some days in-between various trips, I'd be spending at my home in Vienna, Austria. 
Frankly, this was all getting a bit out of control, so I have reduced my workload and got ourselves a brand new home in Spain, too. (He is a pure-bred European and likes it here better than anywhere else.)
I love being at any of our places. I pack a toothbrush only for the flights longer than 2 hrs. For the shorter flights, I save myself the trouble of hauling around the aforementioned toothbrush

. Yeah, this is comfort. 
My BF says that I am awfully complicated and spoiled to no end. Yeah, he is right. I can easily afford it, so why not? There ought to be some little reward for a hard-working dude ever so often, rite? 
I am very happy with all of those complex and maddening arrangements that we have, simply because I can change all of that with only very signatures here and there. It is all my choice only and none of the necessity. 
Yet, cities and countries do not make people happy. Happiness must reside within your solar plexus, and she must go every step of your way. You must define her and groom her on a daily basis. 
SC