BostonPirate
Ijubbinatti
In Texas, European diseases were introduced in the early 1500's, there were Spaniards and Indians all over the place for hundreds of years before the Texas Rangers. It wasn't "just" disease.
Kulindahr Is right. I believe the number I read once was 80 percent of the entire continent having died before the mayflower set sail.
http://en.wikipedia.org/wiki/Population_history_of_indigenous_peoples_of_the_Americas









