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On Topic Discussion 2019 Coronavirus (COVID-19/SARS-CoV-2)

Kulindahr said:
Still have occasional chills, after three days. I also had what to me seems an odd reaction: massive inflammation at the site of an old injury under my right shoulder blade. The pain was bad enough I went to Urgent Care. I thought it was a torn muscle, but after squeezing and prodding the (amazingly cute) physician's assistant decided it was a reaction to the booster-plus-flu injections. My hypothesis is that since it has been injured and inflamed before it was a spot that was vulnerable to new inflammation.
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After every covid shot so far I got mild pain from an old shoulder injury. It happens when I get very sick which isn't often, and sometimes I can detect slight pain there when I'm especially overtired or run down.
 
Kulindahr said:
....So does this mean I had a low antibody count before the booster or that I have a strong immune system that reacts like a while armored division? I'm guessing the latter since I've been around infected people but still test negative... which reminds me, somewhere here I've still got some test kits; I should get them out where I can find them easily.
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Not necessarily.

The new mRNA vaccines use RNA particles that are delivered in a lipid envelope. There's some evidence that the people who are having consistently strong immune reactions (the immunology term is reactogenicity) may be having both an immune response to both the viral spike protein produced by the RNA and the lipid envelope that delivers the RNA.

There's a lot of variability in the responses - from most people who have mild arm soreness on one end, and people who run high fevers, have chills and headaches on the extreme other end. Even within the series of shots it varies - some people had stronger reactions to the first dose, some people had stronger reactions to the second dose. The people who have strong reactions to every dose are rare. You might consider volunteering for a research study that tests your HLA type to see if you're in one of the groups that has an unsual immune response to the vaccines.

Even the strong responses aren't a bad thing. It is still a sign your immune system is recognizing the virus spike protein as a foreign invader. It is just a pain in the ass. When someone tells me that they've had fever, chills and a strong response to one of their COVID vaccine series, I recommend that they take Tylenol before bedtime and plan on a day on the couch watching Netflix or reading. It's better to plan for a day of rest that you don't need than to push yourself and aggravate the fatigue and other symptoms.
 
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KaraBulut said:
Not necessarily.

The new mRNA vaccines use RNA particles that are delivered in a lipid envelope. There's some evidence that the people who are having consistently strong immune reactions (the immunology term is reactogenicity) may be having both an immune response to both the viral spike protein produced by the RNA and the lipid envelope that delivers the RNA.
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Reaction to the lipids? That's something I never would have guessed!

KaraBulut said:
There's a lot of variability in the responses - from most people who have mild arm soreness on one end, and people who run high fevers, have chills and headaches on the extreme other end. Even within the series of shots it varies - some people had stronger reactions to the first dose, some people had stronger reactions to the second dose. The people who have strong reactions to every dose are rare. You might consider volunteering for a research study that tests your HLA type to see if you're in one of the groups that has an unsual immune response to the vaccines.
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How would I go about finding such a study?

KaraBulut said:
Even the strong responses aren't a bad thing. It is still a sign your immune system is recognizing the virus spike protein as a foreign invader. It is just a pain in the ass. When someone tells me that they've had fever, chills and a strong response to one of their COVID vaccine series, I recommend that they take Tylenol before bedtime and plan on a day on the couch watching Netflix or reading. It's better to plan for a day of rest that you don't need than to push yourself and aggravate the fatigue and other symptoms.
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The PA told me to alternate ibuprefen and Tylenol since it's safe to take them together. I've spent two days doing very little; this morning is the first one when I woke up without any symptoms (yesterday was just chills and weakness).

It was tough yesterday; the weather outside was awesome for this time of year and there were things I desperately need to get done. I did a few little things like applying a bit of caulk to pieces for a project when I took Knox out, but mostly I sat and meandered around the web. The plan today is to read a novel and possibly play a strategy game -- though Knox has a habit of getting into mischief when I'm concentrating on something!

I did have to bar my buddy's dog from the house; his presence all too often is not conducive to a peaceful time!
 
Kulindahr said:
Reaction to the lipids? That's something I never would have guessed!
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The mRNA in the vaccine is enclosed in a microlipid envelope. During vaccine testing, they discovered that the lipid without mRNA also triggered an immune response.

One of the problems with vaccines that don't actually contain viruses is that the immune system can take a while to recognize the substance as foreign. This is why many vaccines contain an adjuvant- a substance that triggers the immune system. Apparently, the microlipid also has the advantage of being both a delivery mechanism and an adjuvant.

Kulindahr said:
How would I go about finding such a study?
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You can ask your primary care provider for an immunology referral.

There's still a lot of studies going on about responses to vaccines:
clinicaltrials.gov

Search of: Recruiting, Not yet recruiting Studies | COVID-19 Vaccine Adverse Reaction - List Results - ClinicalTrials.gov

clinicaltrials.gov clinicaltrials.gov


Kulindahr said:
The PA told me to alternate ibuprefen and Tylenol since it's safe to take them together. I've spent two days doing very little; this morning is the first one when I woke up without any symptoms (yesterday was just chills and weakness).

It was tough yesterday; the weather outside was awesome for this time of year and there were things I desperately need to get done.
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It looks like COVID boosters will be like flu shots - there will be a periodic booster than is adjusted for the strains that are circulating. You should probably plan ahead for your boosters to have a day of rest on the day following your boosters.
 
Here's the actual report that was sent to the Senate:


Updated Assessment on COVID-19 Origins

Key Takeaways

Scope Note:
This assessment responds to the President’s request that the Intelligence Community (IC) update its previous judgments on the origins of COVID-19. It also identifies areas for possible additional research. Annexes include a lexicon, additional details on methodology, and comments from outside experts. This assessment is based on information through August 2021.

The IC assesses that SARS-CoV-2, the virus that causes COVID-19, probably emerged and infected humans through an initial small-scale exposure that occurred no later than November 2019 with the first known cluster of COVID-19 cases arisingin Wuhan, China in December 2019. In addition, the IC was able to reach broad agreement on several other key issues.

We judge the virus was not developed as a biological weapon. Most agencies also assess with low confidence that SARS-CoV-2 probably was not genetically engineered; however, two agencies believe there was not sufficient evidence to make an assessment either way. Finally, the IC assesses China’s officials did not have foreknowledge of the virus before the initial outbreak of COVID-19 emerged.

After examining all available intelligence reporting and other information, though, the IC remains divided on the most likely origin of COVID-19. All agencies assess that two hypotheses are plausible: natural exposure to an infected animal and a laboratory -associated incident.
  • Four IC elements and the National Intelligence Council assess with low confidence that the initial SARS-CoV-2 infection was most likely caused by natural exposure to an animal infected with it or a close progenitor virus—avirus that probably would be more than 99 percent similar to SARS-CoV-2. These analysts give weight to China’s officials’lack of foreknowledge, the numerous vectors for natural exposure, and other factors.
  • One IC element assesses with moderate confidence that the first human infection with SARS-CoV-2 most likely was the result of a laboratory-associated incident, probably involving experimentation, animal handling, or sampling by the Wuhan Institute of Virology.
    These analysts give weight to the inherently risky nature of work on coronaviruses.
  • Analysts at three IC elements remain unable to coalesce around either explanation without additional information, with some analysts favoring natural origin, others a laboratory origin, and some seeing the hypotheses as equally likely.
  • Variations in analytic views largely stem from differences in how agencies weigh intelligence reporting and scientific publications and intelligence and scientific gaps.
The IC judges they will be unable to provide a more definitive explanation for the origin of COVID-19 unless new information allows them to determine the specific pathway for initial natural contact with an animal or to determine that a laboratory in Wuhan was handling SARS-CoV-2 or a close progenitor virus before COVID-19 emerged.
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Well, yours truly is now infected with Covid, but since it was caught early, and I have started medication, I hope to be fine. Still, I feel like crap.
 
eddielee said:
Well, yours truly is now infected with Covid, but since it was caught early, and I have started medication, I hope to be fine. Still, I feel like crap.
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It's good they caught it early and started you on meds. It's about 2-3 of feeling crappy and then it should turn around. Keep us posted.
 
COVID-Varian-XBB.jpg
 
eddielee said:
I a

I'm on the mend (I hope), but strangely very weak. I can only do a little before I'm out of breath.
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You need to call your doctor if this shortness of breath is new for you. They may want to have you in for a chest xray and to check your pulse oximetry, just to be sure.
 
eddielee said:
I a

I'm on the mend (I hope), but strangely very weak. I can only do a little before I'm out of breath.
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I have had the shortness of breath and memory problem and extreme fatigue since I had covid in 2020. I was listening to one of my customers talking about long covid and the symptoms ( I had all of them) so I looked it up and there it was. I also had a couple symptoms she didn't mention. I'm not sure there is anything I can do about it though. They say they are figuring out how to treat long covid so if they figure it out I guess I will seek treatment - in the meantime I ALWAYS wear a mask if I am around people and I get all the shots when they come out ASAP.

It would be great if they could really cure long covid but I don't have much hope as it has been a long time now - I got used to it and have learned to live with it (lots of naps) :)

When you are out of breath make sure you sit down and pay attention to your breathing and try to breath deep and show and stay as calm and relaxed as you can -I found that helps ALOT.

Wishing you the best!
(*8*)
 
cabinfever said:
I have had the shortness of breath and memory problem and extreme fatigue since I had covid in 2020. I was listening to one of my customers talking about long covid and the symptoms ( I had all of them) so I looked it up and there it was. I also had a couple symptoms she didn't mention. I'm not sure there is anything I can do about it though. They say they are figuring out how to treat long covid so if they figure it out I guess I will seek treatment - in the meantime I ALWAYS wear a mask if I am around people and I get all the shots when they come out ASAP.

It would be great if they could really cure long covid but I don't have much hope as it has been a long time now - I got used to it and have learned to live with it (lots of naps) :)

When you are out of breath make sure you sit down and pay attention to your breathing and try to breath deep and show and stay as calm and relaxed as you can -I found that helps ALOT.

Wishing you the best!
(*8*)
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That is good advice. I did find out that my lungs are congested and I'm now on doxycycline to clear that up.
I do hope the fatigue will go when my lungs clear. I hate to be going half steam during the holiday season.
 
eddielee said:
That is good advice. I did find out that my lungs are congested and I'm now on doxycycline to clear that up.
I do hope the fatigue will go when my lungs clear. I hate to be going half steam during the holiday season.
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That's what I suspected - that you might have a bronchitis or secondary pneumonia. Glad they caught it early.

If you don't have a finger pulse ox, they're about $15-20 on Amazon.
 
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